This study sought to evaluate the interactions among social, economic, and environmental factors that influence the implementation of business ethics and corporate social responsibility (CSR) frameworks in livestock-based enterprises. The study was conducted in Turkana in Kenya, Karamoja in Uganda, and Kapoeta in South Sudan. 9 primary, secondary, and cross-border livestock marketplaces were designated as case study locations, involving 171 statistically selected study participants. The study objectives were to (i) delineate business ethics and the application of corporate social responsibility within the livestock sector, (ii) evaluate the economic, legal, ethical, and altruistic components of CSR as implemented in livestock markets, and (iii) propose strategies for integrating business ethics and CSR into livestock business operations in dryland production and marketing environments. The study highlights that while livestock markets aim for profitability and adhere to legal and ethical standards, they fall short due to limited training, exposure, and resources. It emphasizes the importance of altruism alongside profitability, advocating for a collaborative business model that addresses competitive culture and socio-economic benefits. Ethical practices enhance market integrity and information flow, while legal compliance promotes oversight. To improve operational efficiency in livestock-based enterprises, securing resources and mentorship is crucial. Innovation and societal partnerships are essential for addressing disparities and enhancing corporate social responsibility, with an emphasis on government enforcement of these principles to improve corporatesociety relations and overall livestock sector performance.