This research investigates how to dismantle systemic inequalities and create a more just and equitable society through the implementation of Social Justice, Diversity, Equity, and Inclusion (SDEI) initiatives. Main topics: Root causes of systemic inequalities within a specific context (e.g., education, workplace, healthcare). Effectiveness of existing SDEI initiatives in addressing these inequalities. Evidence-based strategies to promote diversity, ensure equity, and foster a more inclusive environment. Key arguments: Systemic inequalities stem from historical and ongoing biases, power structures, and resource allocation. Existing SDEI initiatives often have limited effectiveness and require a more targeted approach. Implementing evidence-based strategies like culturally responsive teaching (education), sponsorship programs (workplace), and cultural competency training (healthcare) can create a more just and equitable environment. Methodological approach: Literature review of recent SDEI research within the chosen context. Analysis of existing SDEI initiatives and their outcomes. Identification of best practices and development of evidence-based recommendations. Significance: This research informs the development and implementation of more effective SDEI initiatives. It contributes to dismantling systemic inequalities and promoting social justice across various contexts. Audience: Scholars and researchers in the field of SDEI. Policymakers and practitioners working on diversity and inclusion issues. Individuals and organizations committed to creating a more just and equitable society.