This study aims to examine how the psychopathological symptoms that accompany substance use disorders are knocked on a multi -variable plane. In particular, psychological variables such as depression, impulsivity and attention deficit, as well as societies on substance use behavior, were investigated. The research is designed with mixed method approach; Beck Depression Scale (BDO), Barratt impulsivity scale (BIS-11) and Stroop test were used as quantitative data collection tools, and qualitative data were obtained through semistructured interviews. In the analysis, statistical methods such as Pearson correlation coefficient, multiple regression, hierarchical modeling and opening factor analysis were used. Findings show that depression and impulse levels significantly predicate the use of substances, especially in particular, depressive symptoms play a fundamental role in both the onset and maintenance of addiction behavior. In addition, it was found that structural variables such as low education level, unemployment and social exclusion increase and reinforce addiction. Factor analysis results showed that psychopathological spouse diagnoses were clustered in two basic dimensions (mood -based and impulsive -based); This structure supported the need to develop individual intervention strategies in treatment planning. Neuropsychological assessments confirm that substance use disorder is not only behavioral, but also a cognitive and neurobiological based structure with findings such as impaired attention processes and impulse control. The results of the research reveal that a multidimensional approach that evaluates the individual's spiritual pattern together with social, cultural and biological layers will be more effective in understanding and intervention of addiction.