The study investigates the effectiveness of inter-departmental collaboration between the South African Police Service (SAPS), the Department of Social Development (DSD), and the justice system in managing domestic violence cases. It aims to identify challenges, assess coordination mechanisms, and provide recommendations to improve case management, victim support, and policy implementation. Despite legal frameworks such as the Domestic Violence Act (1998) and the National Strategic Plan on Gender-Based Violence and Femicide (NSP-GBVF), domestic violence remains pervasive in South Africa. Fragmented interdepartmental collaboration, operational inefficiencies, and limited stakeholder engagement have hindered effective management, delaying victim support and reducing prosecution success rates. A systematic qualitative research design was adopted, combining document analysis, case studies, and semi-structured interviews with officials from SAPS, DSD, and the justice system. The study also incorporated perspectives from community leaders, traditional authorities, and civil society actors. Data were analyzed thematically to identify patterns, challenges, and best practices in interdepartmental collaboration. Communication and coordination among SAPS, DSD, and the justice system are inconsistent, with informal networks often replacing structured protocols. Operational challenges include resource constraints, role ambiguity, policypractice gaps, and insufficient training. Effective collaboration improves victim-centered outcomes, including timely protection, psychosocial support, and higher case resolution rates. Multi-stakeholder engagement, including community leaders, church fraternities, private sector actors, and diaspora, strengthens service delivery and prevention efforts. Digital tools, shared case management systems, and joint task teams significantly enhance inter-agency coordination and accountability. The study demonstrates that robust inter-departmental collaboration is critical to managing domestic violence cases effectively. Structured communication, victim-centered approaches, stakeholder engagement, and evidence-based policy implementation are essential for improving operational efficiency, victim protection, and societal outcomes. The findings provide actionable recommendations for government, law enforcement, social development, communities, and other stakeholders to foster a coordinated and sustainable response to domestic violence in South Africa