This systematic study investigates the multifaceted implications of implementing evidence-based policing (EBP) within the diverse contexts of the Global South. The purpose of this study is to comprehensively analyze the potential benefits and inherent challenges associated with adopting EBP in these regions, considering their unique socio-economic, political, and institutional landscapes. The central problem statement addressed is the limited understanding of how EBP, largely conceptualized and studied in the Global North, translates and impacts policing practices, effectiveness, and community relations in the Global South. The main contribution of this research lies in its systematic synthesis of existing literature, identification of key contextual factors influencing EBP adoption, and the development of a nuanced framework for understanding its implications in resource-constrained and often politically complex environments. Employing a methodology of systematic literature review, this study will identify, evaluate, and synthesize empirical research, theoretical frameworks, and case studies relevant to EBP in the Global South. The analysis will focus on themes such as resource allocation, public safety outcomes, accountability mechanisms, community engagement, and organizational change, while also critically examining challenges related to data availability, research capacity, and contextual relevance. The conclusion will offer a synthesized understanding of the opportunities and obstacles for EBP in the Global South, highlighting critical considerations for policymakers, practitioners, and researchers seeking to promote evidence-informed policing in these vital regions. It will also identify key areas for future research and offer recommendations for the responsible and effective adaptation of EBP principles in diverse Southern contexts.