The concept of regionalism in literature is referred to as the exploration of the specifics of the characters, dialect, customs, culture, and topography, which belong to a certain region. In this paper, a comparative analysis has been done on two of the most representative fictional geographies of the twentieth-century literature, R.K. Narayan’s Malgudi, and William Faulkner’s Yoknapatawpha County. The two authors are both praised for their creation of such creative spaces that form the central setting of most of their literary work. To R.K.Narayan, Malgudi is a fictional South-Indian town, which is a microcosm of the Indian society and which has the differentiation of the traditional society into the influx of the modern western culture. The realism and objectivity with which Narayan describes the middle-class lifestyle characterizes Narayan’s regionalism, the setting often takes the place of a character. Indeed, it has been termed by some as the real hero of the story. In the same way, William Faulkner created Yoknapatawpha County, which is a fictitious area that is based on his own Lafayette County in Mississippi. Faulkner uses this setting to explore the inner world of the American South, questioning both its complex social set up and its tragic racial past and the communal memory that fills the residents. This paper reaffirms that Narayan is a great regional novelist, as it compares his expertise on the local colour tradition to that of Faulkner. The paper examines how the two authors use accurate topographical description and local traditions to base their stories on a touchable reality and at the same time exploring universal human issues. Furthermore, it deals with interdependence of the characters and the surroundings under the premise that these fictional spaces are essential in depicting their cultures as they are. Through the analysis of the chosen works, the study demonstrates how Malgudi and Yoknapatawpha County serve as medium of transition between the specific and the general thus making Narayan and Faulkner, titanic heroes in regional fiction.